1.       Be reasonable about expectations
Get a basic idea of your expected salary on payscale.com
Try to relate previous work experience to potential jobs
Be realistic about job duties from previous jobs

2.     Talk to a career counselor from your school
This is a free option and they can quickly get you heading in the right direction and usually have several job opportunities.

3.    Use your network
Companies are moving away from online hiring and other traditional job postings.  Referral bonuses for employee referrals are on the rise.  Talk to your friends, keep alert for friends and acquaintances that have job opportunities available.  Use your alma matter, they are full of job postings catered to people just finishing up a degree. 

Here is a great article about using your network at Career Know How.

Remember, you don't need to find a million job opportunities, just one that ends up being the right.

4.      Understand what skills you need
Figure out the skills you already possess - Write them down, how can you make them better?
Work on the ones you need to improve - Write them down and steps and a time line to improve

5.      Once Hired, master your job, prepare for next role
Master your job, become the go-to person, it will take more effort upfront, but the work will pay off when you stand out as the leader in your area.  Don't be afraid of excelling at even the smallest of tasks.  The payoffs are huge and being noticed for the small things will make a big difference.
Do what no one else is doing - find out what will make you stand ahead of the pack!